Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 6622
Gene Symbol: SNCA
SNCA 		0.800 Biomarker disease GENOMICS_ENGLAND
Entrez Id: 6620
Gene Symbol: SNCB
SNCB 		0.700 Biomarker disease GENOMICS_ENGLAND
Entrez Id: 6620
Gene Symbol: SNCB
SNCB 		0.700 Biomarker disease GENOMICS_ENGLAND A β-synuclein mutation linked to dementia produces neurodegeneration when expressed in mouse brain. 21045828 2010
Entrez Id: 6622
Gene Symbol: SNCA
SNCA 		0.800 GeneticVariation disease UNIPROT The new mutation, E46K, of alpha-synuclein causes Parkinson and Lewy body dementia. 14755719 2004
Entrez Id: 6622
Gene Symbol: SNCA
SNCA 		0.800 GeneticVariation disease LHGDN Pathologically confirmed Lewy body disease clinically characterized by progressive parkinsonism and cognitive dysfunction is caused by SNCA duplication. 18413475 2008
Entrez Id: 6622
Gene Symbol: SNCA
SNCA 		0.800 Biomarker disease LHGDN A triplication of the alpha-synuclein gene was found to cause autosomal dominant Lewy body disease in two distinct families. 15622440 2005
Entrez Id: 6622
Gene Symbol: SNCA
SNCA 		0.800 GeneticVariation disease LHGDN Abundant neuritic inclusions and microvacuolar changes in a case of diffuse Lewy body disease with the A53T mutation in the alpha-synuclein gene. 15981014 2005
Entrez Id: 6622
Gene Symbol: SNCA
SNCA 		0.800 Biomarker disease LHGDN Interaction between Abeta peptide and alpha synuclein: molecular mechanisms in overlapping pathology of Alzheimer's and Parkinson's in dementia with Lewy body disease. 16947080 2006
Entrez Id: 6622
Gene Symbol: SNCA
SNCA 		0.800 Biomarker disease LHGDN Patterns and stages of alpha-synucleinopathy: Relevance in a population-based cohort. 18362284 2008
Entrez Id: 6622
Gene Symbol: SNCA
SNCA 		0.800 GeneticVariation disease LHGDN SNCA multiplication is not a common cause of Parkinson disease or dementia with Lewy bodies. 15304594 2004
Entrez Id: 6622
Gene Symbol: SNCA
SNCA 		0.800 Biomarker disease LHGDN Abnormal alpha-synuclein interactions with rab3a and rabphilin in diffuse Lewy body disease. 15207266 2004
Entrez Id: 2629
Gene Symbol: GBA
GBA 		0.500 GeneticVariation disease LHGDN The spectrum of parkinsonian manifestations associated with glucocerebrosidase mutations. 18852351 2008
Entrez Id: 7054
Gene Symbol: TH
TH 		0.330 Biomarker disease LHGDN Reduced striatal tyrosine hydroxylase in incidental Lewy body disease. 17985144 2008
Entrez Id: 348
Gene Symbol: APOE
APOE 		0.200 GeneticVariation disease LHGDN The role of APOE genotype in Lewy body dementia (LBD) is still unknown as well as the relationship between APOE genotype and cholesterol levels. 16956959 2006
Entrez Id: 120892
Gene Symbol: LRRK2
LRRK2 		0.100 Biomarker disease LHGDN Lrrk2 G2019S was observed in approximately 2% (n = 8) of our Parkinson's disease/Lewy body disease cases (n = 405). 16437559 2006
Entrez Id: 6531
Gene Symbol: SLC6A3
SLC6A3 		0.100 Biomarker disease LHGDN Dopamine transporter loss visualized with FP-CIT SPECT in the differential diagnosis of dementia with Lewy bodies. 15210531 2004
Entrez Id: 351
Gene Symbol: APP
APP 		0.070 Biomarker disease LHGDN Imaging amyloid deposition in Lewy body diseases. 18794492 2008
Entrez Id: 351
Gene Symbol: APP
APP 		0.070 Biomarker disease LHGDN Validation of amyloid-beta peptides in CSF diagnosis of neurodegenerative dementias. 17339876 2007
Entrez Id: 351
Gene Symbol: APP
APP 		0.070 Biomarker disease LHGDN Interaction between Abeta peptide and alpha synuclein: molecular mechanisms in overlapping pathology of Alzheimer's and Parkinson's in dementia with Lewy body disease. 16947080 2006
Entrez Id: 5071
Gene Symbol: PRKN
PRKN 		0.020 AlteredExpression disease LHGDN S-nitrosylation of parkin regulates ubiquitination and compromises parkin's protective function. 15105460 2004
Entrez Id: 358
Gene Symbol: AQP1
AQP1 		0.010 AlteredExpression disease LHGDN Significant increased expression levels of AQP1 (as revealed with two different antibodies) and AQP4 were seen in CJD, but not in advanced AD and DLB cases when compared with controls. 16871401 2006
Entrez Id: 361
Gene Symbol: AQP4
AQP4 		0.010 AlteredExpression disease LHGDN Significant increased expression levels of AQP1 (as revealed with two different antibodies) and AQP4 were seen in CJD, but not in advanced AD and DLB cases when compared with controls. 16871401 2006
Entrez Id: 22895
Gene Symbol: RPH3A
RPH3A 		0.010 Biomarker disease LHGDN Abnormal alpha-synuclein interactions with rab3a and rabphilin in diffuse Lewy body disease. 15207266 2004
Entrez Id: 4929
Gene Symbol: NR4A2
NR4A2 		0.010 GeneticVariation disease LHGDN A common NURR1 polymorphism associated with Parkinson disease and diffuse Lewy body disease. 12756136 2003
Entrez Id: 6622
Gene Symbol: SNCA
SNCA 		0.800 GeneticVariation disease GWASCAT Investigating the genetic architecture of dementia with Lewy bodies: a two-stage genome-wide association study. 29263008 2018